Disease relations: the species was found naturally infected with Plasmodium vivax and Plasmodium falciparum in Brazil. Experimentally, the production of sporozoites of Plasmodium vivax and Plasmodium falciparum in the salivary glands was comparable with that of Nyssorhynchus darlingi (Klein et al., 1991). It is considered a malaria vector in the western area of the Amazon region (Forattini, 2002).
Immature stages develop in swampy flat terrain that is formed by the overflow of watercourses (Forattini, 2002). The female is mainly endophilic and anthropophilic (Klein & Lima, 1990; Klein et al., 1991).